Liver cancer is the growth and spread of unhealthy cells in the liver. Cancer that starts in the liver is called primary liver cancer (Hepatocellular carcinoma-HCC).

HCC is a primary liver cell cancer that follows chronic inflammation and cirrhosis, with a high prevalence in sub-Saharan due to the endemicity of chronic viral hepatitis B and C infection.

HCC is the 5th most common cancer in males and the second most common cause of cancer death in all males. In females, HCC is the 8th most common cancer and the 6th most common cause of cancer related deaths in females.